The promotion of physical activity as a way to maintain physical, social and emotional health cannot be understated. At Santa Maria we know that involvement in sport can increase skills, leadership, teamwork and dedication. The College facilities and the availability of expert coaching supports many athletes to reach their peak performance and teams to excel in the various competitions.
The College is a member of the Secondary Catholic Sports Association (SCSA) which provides girls with the chance to compete against other elite sportswomen from Catholic schools in Melbourne and Geelong. Alongside this competition, the College competes at a State and National Level in Volleyball and has achieved amazing success in the past decade.
The sports on offer at an interschool level include:
| SCSA Athletics | SCSA Badminton | SCSA Basketball | SCSA Soccer |
| SCSA Hockey | Great Vic Bike Ride | SCSA Netball | SCSA Swimming |
| SCSA Aerobics | SCSA Volleyball | SCSA Softball | SCSA Table Tennis |
| SCSA AFL | SCSA Futsal | SCSA Tennis | |
| SCSA Indoor Cricket | State/National Volleyball | Triathlon or Gatorade Triathlon | SCSA Cross Country |